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New AI-Powered Mobile App Delivers Early Prediction of Heart Attack or Stroke

Before Health Intelligence Ltd.

Before Health Intelligence, Ltd. today emerged from stealth and announced a new mHealth app called Antshrike ™ that uses AI to transform wearable device data into highly precise and specific predictive cardiovascular health warnings. As an iOS app, Antshrike uses proprietary AI algorithms to identify early warning signs of critical cardiovascular events, such as heart attacks or strokes, with high predictive accuracy for individuals at risk. The app processes biometric time-series data collected by commercially available Apple smart phones and smart watches, calculates individual risk of critical events in real time and predicts when and how changes in a patient’s health states may occur. By notifying patients of imminent danger in advance, Antshrike enables timely intervention by healthcare providers, paving the way for personalized medical intervention and treatment and improved medical outcomes. “In South America, the Antshrike bird warns primates of upcoming dangers,” said Before Health Intelligence CEO & co-founder Ekaterina Mitricheva, MD, PhD. “We developed our new digital health app by the same name to warn those at risk of major ischemic cardiovascular events before they take place. With cardiovascular disease as the number one cause of death worldwide, there is an urgent need to predict and prevent heart attacks and strokes.” The Antshrike mHealth app: Passively monitors health status without interrupting daily routines, social interactions and work habits Predicts the danger and timing of cardiovascular events with more than 85% accuracy in a personalized manner Uses proven science based on decades of research, more than 130 billion data points analyzed by Before Health Intelligence’s scientists, as well as open source CDC data from tens of thousands of individuals Assures HIPAA-compliant patient privacy by preprocessing individual patient data (not patient records) on a patient’s phone with anonymized preprocessed values that can never be traced back to any specific person Requires no manual input of data or reliance on expensive hospital equipment and procedures Assists healthcare providers in saving more lives since timely predictive interventions are known to reduce the probability of lasting effects or fatality Antshrike uses two layers of AI, static and dynamic, to calculate an individual’s risk of critical events in real-time. The static layer processes data entered by an individual to determine an initial risk score, and the machine learning algorithm is trained on over 500,000 CDC datapoints of approximately 23,000 individuals. The dynamic layer collects and analyzes biometric time-series from smart watches in real-time, uses the proprietary AI algorithm to identify early warning signs of critical state transitions, and then delivers a personalized, time-sensitive risk score for an upcoming major ischemic cardiovascular event. The freemium app is expected to be available in the U.S. in 2025. To become a partner or learn more about the product, visit https://www.before-intelligence.com/contact. About Before Health Intelligence Ltd. Before Health Intelligence, a medical device manufacturer developing software-as-a-medical device (SaMD), offers mobile applications that identify the early warning signs of critical events in complex diseases. The apps analyze each individual’s health data, recorded by leading smart watch brands in combination with proprietary AI algorithms and data sets, as well as open source data from the Center for Disease Control (CDC). This continuous monitoring alerts individuals of early warning signs of critical cardiovascular events (e.g., heart attacks or strokes) or neuropsychiatric events (e.g., alcohol addiction relapse), enabling timely medical intervention and improved survival rates. Founded in 2022, the Before Health Intelligence team is comprised of highly skilled medical professionals, mathematicians, physicists and programmers with research experience at institutions such as Princeton University, Max Planck Society and MIT. Learn more at https://www.before-intelligence.com and follow the company on LinkedIn. Contact Details Rainier Communications Michelle Allard McMahon or Jenna Desimone beforehealth@rainierco.com Company Website https://www.before-intelligence.com/

November 19, 2024 07:45 AM Eastern Standard Time

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Bacula Announces Version 18.2 of its Backup and Recovery Software with New HPC Features

Bacula Systems

Expanding its leadership in high security, high performance backup and recovery for HPC and other demanding IT environments, Bacula Systems today announced a host of new features in the latest version of its backup and recovery software. Version 18.2 introduces powerful new features that enhance Bacula’s ability to support backup across a wide variety of different Virtual Machine-types. This comes as the industry continues its shift towards more economical alternatives to traditional VM’s. "This latest Bacula release underscores its unique ability to handle backups for numerous virtual machine types, enabling organizations to boost security, comply with regulatory demands, and achieve substantial cost savings," said Frank Barker, CEO of Bacula Systems. The new features in Version 18.2 further strengthen Bacula's top-tier security capabilities while enhancing its adaptability to meet the demands of complex IT environments—especially in terms of supporting various VM types and workloads. Its broad hybrid cloud qualities are now expanded with Lock function, immutability synchronization and storage class function for all cloud providers. Bacula’s advanced security features a number of innovative security tools, such as data poisoning detection, centralized encryption, FIPS 140-3 compliance, and an extensive cybersecurity dashboard for single-pane security control. Bacula now offers advanced backup and recovery capabilities for the following Virtual Machines: Nutanix, VMware, Hyper-V, KVM, Xen, XCP-ng, RHV and OpenStack. XCP-ng support now includes Secure mode. Version 18.2 offers Single Item Restore to all Hypervisor plugins. It also delivers Hypervisor to Cloud (EC2) conversion capabilities, a feature that provides the ability to send On-Premise backed-up virtual machines to the cloud to avoid lock-in situations with Hypervisor vendors and to help with migration strategies. Increased Hyper-V capabilities Bacula’s latest version offers the following enhancements for Hyper-V WinAPI to complement its ability to backup Virtual Machines in an agentless manner: Support for any kind of deployment (standalone or clustered) Advanced boot handling (UEFI based systems, device order management) Full, Differential or Incremental backup Data directly streamed from the source to the destination storage without the need of reserving any space on the backup agent running the process. Version 18.2 makes further additions to its comprehensive Kubernetes module, adding intelligence to select automatically the better backup mode or to protect additional services within a cluster such as the Ingress resource manager, among other improvements to increase its flexibility to support any kind of Kubernetes deployment. Applications and Databases additions include: Amazon Relational Database (RDS) Plugin: It is now possible to not only orchestrate Database as a Service backups in Amazon cloud, but also to extract the data and have it available OnPremise for increased protection or for migration purposes. M365 Plugin improvements: SharePoint module now has page-level recovery capabilities. Exchange module can now export its data to PST format and the new Activity module was added to protect logs on the actions performed on the Cloud service, which complements one of the most comprehensive M365 solutions in the industry. HPC Leadership: Bacula’s dominance in the HPC space is underlined by its remarkable scalability, Quobyte support and efficiency improvements to Bacula’s Big File Split module, which greatly accelerates the backup of environments with billions of files. ZFS advanced support, through extremely high performance design, will soon be available. In addition, Bacula has further developed its renowned Deduplication capability, with new and more powerful scan & recovery tools. "Bacula offers licensing without capacity limits, supports 34 different operating systems, leads the industry in security, scales extensively, provides in-cloud functionality, and is compatible with more hypervisor and container types than any other backup provider. Its unmatched flexibility delivers significant advantages for our military, government, e-commerce, ISV, and HPC clients"said Jorge Gea, CTO, Bacula Systems. Bacula Systems customers include NASA, Navisite, Texas A&M University, Sky PLC, Warner Bros, Locaweb and many more. About Bacula Systems: Bacula Enterprise Edition is a highly scalable backup and recovery software for large organizations, data centers and MSPs. www.baculasystems.com OpenStack and the OpenStack logos are trademarks of the OpenStack Foundation. Quobyte is a registered trademark of Quobyte Inc. Contact Details Bacula Systems Corp Rob Morrison +41 21 508 29 36 rob.morrison@baculasystems.com Company Website https://www.baculasystems.com/

November 19, 2024 07:12 AM Eastern Standard Time

Novela and Film Star Carlos Ponce, Brilla Media, Numatec, and Chicano Hollywood Team Up to Launch Minivela: A Bold New Era for American Latino Filmmakers, Creators, and Advertisers

Brilla Media

Novela and film star Carlos Ponce, Brilla Media, Numatec, and Chicano Hollywood are partnering to launch Minivela, a digital shorts joint venture that starting in January marks a bold new era for American Latino filmmakers, creators, and advertisers. The announcement was made today in Las Vegas as part of the 26th annual ANA Multicultural Marketing & Diversity Conference that is taking place at the Bellagio. (See the Minivela trailer here ). True to its name, Minivela combines the fast-paced nature of vertical short-form content with the iconic, entertaining essence of the telenovela—a genre created by Latinos. The advertiser-supported Minivelas, – ranging from 10 to 90 minutes – are being developed collaboratively with filmmakers and influencers in English, Spanish, or bilingually, depending on the organic needs of the stories. “This is a groundbreaking journey that we believe will empower Latino storytellers and drive U.S. Hispanic digital advertising for years to come,” said Manny Ruiz, who will serve as the Chief Creative Officer and Executive Producer of the joint venture alongside Ponce and will also write and direct select Minivelas. “Our focus is on consistently producing universally appealing stories with a vision that extends beyond Minivelas. A key pillar of our innovative approach is to catapult select narratives into independent features or series.” “Minivela represents a beacon of hope, experimentation, and opportunities for Latino creatives at a time when the Hollywood system is undergoing a much-needed reboot,” said Ponce, who in addition to executive producing, will also act and/or direct in select Minivelas. “I’m thrilled that our Latino-owned venture will address the representation gap for our community organically, and that our operations are driven by pioneers in Latino social media, digital media, and adtech.” Minivela primarily targets American Latinos 18-34, and will commence weekly in January with content verticals that feature romantic comedies, strange happenings, the supernatural, and even La Mala Suegra (The evil mother-in-law). The family-friendly digital films will be accessible free on Minivela’s YouTube, and social media channels, as well as thru adtech conglomerate, Numatec’s distribution partnerships. Combined with Brilla Media’s Nuestro Media network, brand sponsors will be able to secure USH audiences effectively across digital, CTV, and other platforms. Let the Films Roll! A cornerstone of Minivela is Chicano Hollywood, the influential L.A.-based production, media, and magazine company that produces the annual Elevate conference for Latino filmmakers, and is the exclusive West Coast production arm of the company. Chicano Hollywood is already producing one of the platform’s early bets, a feel good romcom called “Cholita Takes L.A.” that is being directed by a rising Chicana director. Cholitas, Cholos, and Cholas shine in this story about a young Bolivian luchadora and aspiring fashion designer who journeys to L.A. to care for her ailing grandmother—only to discover she must also overcome culture clashes and personal challenges on her path to unexpected love. “Minivela is putting deeds before words, and that’s something the Latino film community will root hard for, and why we’re a proud partner,” said Johnny Murrillo, founder and CEO of Chicano Hollywood. “It’s also critical to note that for Minivela, the projects must be Latino-produced but the stories must appeal to audiences universally even outside our core Hispanic community. We have some fun ones lined up!” A Force For Good Being a force for good also matters deeply to Minivela’s founders. “We’re going to push boundaries and prove that you can be creative and positively provocative without leaning on the usual violent drug dealers, and other tired tropes that diminish our community,” said Angela Sustaita-Ruiz, chairwoman of Brilla Media, the parent company of Minivela. “I believe Minivela will also prove to be a catalyst for many Latinas and Latinos who one day will remember that they got their big Hollywood break writing/directing, producing and/or acting in a Minivela.” About Minivela Co-headquartered in Los Angeles and Miami, Minivela is an American Latino-owned and operated company dedicated to producing advertiser-supported digital shorts created by Latino filmmakers and creators. The company is a joint venture between actor Carlos Ponce, Brilla Media, and Numatec. Minivela merges the fast-paced appeal of short-form vertical content with the iconic, entertaining essence of the telenovela—a genre proudly created by Latinos. These advertiser-supported Minivelas, ranging from 10 to 90 minutes, are developed in collaboration with filmmakers and influencers, featuring content in English, Spanish, or a bilingual mix based on the organic needs of the stories. Minivela content is available through its YouTube, and social media channels, as well as through adtech conglomerate, Numatec’s distribution partnerships, which include CTV. About Brilla Media Ventures Brilla Media Ventures provides engaging cultural content for multicultural marketers through its owned and operated platforms, Nuestro Stories, Minivela, Nuestro Studios, and Brilla Latina. Offerings also include programmatic advertising technology services for scalable media delivery, digital shorts, influencer marketing, creative studio services, and brand activations. Brilla Media is a certified women-owned Minority Business Enterprise (MBE) by the National Minority Supplier Development Council (NMSDC). The company is led by Angela Sustaita-Ruiz, its chairwoman, and Manny Ruiz, creators of Hispanicize, and trailblazers in the Hispanic media, social and influencer marketing industries, the Latino press release wire industry, and the first network of Hispanic print media companies online. About Numatec Based in Miami, FL, NUMATEC is a holding company that owns and operates 11 subsidiaries in its fast-growing portfolio. The company actively seeks out new opportunities to scale companies in the AdTech and MarTech industries to build the world’s premier network of service providers for today’s global brands. Uniquely positioned to offer superior service and value, NUMATEC boasts a global footprint across 22 countries that is unparalleled. Learn more at www.NUMATEC.com / www.ekn.solutions/usa/media/ About Chicano Hollywood Chicano Hollywood is a L.A.-based production, media, and magazine company that produces the annual Elevate conference for Latino filmmakers, and is the exclusive West Coast arm of Minivela. Chicano Hollywood is dedicated to elevating Chicano/Latino stories, creators, and talent across the entertainment spectrum. With a mission to champion authentic representation and bring Chicano/Latino-driven narratives to the forefront, Chicano Hollywood is empowering a new wave of creatives in film, television, and digital media. Contact Details Brilla Media Rameh Echeverri +1 305-303-2322 Rameh@brillamedia.com Company Website https://www.facecuba.org/

November 18, 2024 02:21 PM Eastern Standard Time

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Mercado Bitcoin Launches MBRL Stablecoin on the TRON Blockchain, Pegged to the Brazilian Real

Mercado Bitcoin

São Paulo, November 18, 2024 - Mercado Bitcoin (MB), the largest digital asset platform in Latin America, announces the launch of MBRL stablecoin on the TRON blockchain. The MBRL stablecoin presents an innovative means of payment that combines the trust and stability of Brazilian fiat currency with the utility and ease of tokenization. The MBRL stablecoin is an MB project that uses the TRON network through integration with the blockchain. This integration aims to create a fast, accessible and scalable smart contract platform. MBRL is designed to act as a reliable store of value with liquidity for withdrawals around the clock, including weekends and public holidays. Additionally, MBRL can be easily integrated into blockchain wallets, DeFi platforms, and dApps, making it incredibly versatile and easy to use. Lucca Benedetti, Product Analyst at MB, commented, "The introduction of MBRL is a significant milestone for both MB and the growing crypto community in Brazil. The TRON blockchain has already seen widespread adoption in the region. We are further solidifying our presence within the TRON ecosystem through the launch of MBRL. I'm looking forward to seeing the positive effects MBRL will bring”. Sam Elfarra, Community Spokesperson at TRON DAO commented, "We are thrilled to see MRBL launch in the TRON ecosystem. The launch is a significant step forward in our mission to provide accessible, efficient, and scalable blockchain solutions globally, showcasing the versatility and robustness of the TRON network. I believe MRBL will play a key role in accelerating the adoption of blockchain technology across the region". TRON network, the trusted network for developers, institutions, and individuals worldwide, is a layer-1 open-source blockchain protocol with over 271 million user accounts. With a total transfer volume exceeding $14 trillion, TRON stands out for its ability to efficiently handle both large and small transactions. Its speed and cost-effectiveness make it especially popular among retail users for fast, frequent, low-value transactions like remittances, micropayments, and peer-to-peer transfers. Leveraging the TRON network will enable MB to offer users faster, more reliable asset transfers with lower fees, enhancing the overall efficiency and accessibility of transactions. Customers in supported jurisdictions can now buy MBRL on Mercado Bitcoin's offer book or issue it directly with a deposit of BRL. They then receive MBRL stablecoins, which can be easily transacted in just a few seconds. Management and custody of the assets are carried out by MB Pay, Mercado Bitcoin's payment institution. About Mercado Bitcoin With 4 million customers in 11 years of operation, Mercado Bitcoin is the leading digital asset investment platform in Latin America and a benchmark in blockchain and the tokenized economy, operating with the highest standards of transparency and financial integrity. It is Brazil's first crypto unicorn and has been audited since 2018, and since 2022 by EY - one of the world's largest auditing firms. Mercado Bitcoin - Agência Pub Treicy Keller: treicy.keller@agencia.pub | +55 11. 98990-2218 Patrícia Martins: patricia.martins@agencia.pub | +55 24. 99942-3041 Anne Fadul: anne.fadul@agencia.pub | +55 11. 99335-4527 Chico Marcelino: chico.marcelino@agencia.pub | +33. 76945-0275 About TRON DAO TRON DAO is a community-governed DAO dedicated to accelerating the decentralization of the internet via blockchain technology and dApps. Founded in September 2017 by Justin Sun, the TRON network has continued to deliver impressive achievements since MainNet launch in May 2018. July 2018 also marked the integration of BitTorrent, a pioneer in decentralized Web3 services, boasting over 100 million monthly active users. The TRON network has gained incredible traction in recent years. As of November 2024, it has over 271 million total user accounts on the blockchain, more than 8.9 billion total transactions, and over $18 billion in total value locked (TVL), as reported on TRONSCAN. In addition, TRON hosts the largest circulating supply of USD Tether (USDT) stablecoin across the globe, overtaking USDT on Ethereum since April 2021. The TRON network completed full decentralization in December 2021 and is now a community-governed DAO. Most recently in October 2022, TRON was designated as the national blockchain for the Commonwealth of Dominica, which marks the first time a major public blockchain partnered with a sovereign nation to develop its national blockchain infrastructure. On top of the government’s endorsement to issue Dominica Coin (“DMC”), a blockchain-based fan token to help promote Dominica’s global fanfare, seven existing TRON-based tokens – TRX, BTT, NFT, JST, USDD, USDT, TUSD, have been granted statutory status as authorized digital currency and medium of exchange in the country. TRONNetwork | TRONDAO | Twitter | YouTube | Telegram | Discord | Reddit | GitHub | Medium | Forum Media Contact Yeweon Park press@tron.network Contact Details Patrícia Martins patricia.martins@agencia.pub

November 18, 2024 12:58 PM Eastern Standard Time

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Henson Group Named Managed Services Provider of the Year at the 2024 Ingram Micro ONE Innovation Summit

Spark Metro

Henson Group, a leading provider of cloud solutions and managed services, is proud to announce it has been awarded the Ingram Micro Managed Services Provider of the Year. Ingram Micro is a leading technology company for the global information technology ecosystem with the ability to reach nearly 90% of the world’s population. The award was presented as part of the 2024 INGRAM MICRO ONE INNOVATION SUMMIT, held from November 6-8 in Maryland. The Ingram Micro Partner Awards program honors the success of top-performing channel partners who have measurably exhibited an elite ability to drive business growth and positively impact the IT ecosystem with the support of Ingram Micro. This year’s honorees have displayed extraordinary levels of innovation, advocacy, performance, and sales success in 2024. Ingram Micro’s Managed Services Provider of the Year award recognizes Henson Group for consistently demonstrating exceptional expertise and innovation across multiple solution areas. Their dedication to innovation and unwavering commitment to customer satisfaction have made them an industry leader. Henson Group is celebrated for providing comprehensive cloud solutions, including Azure Spend Management, Azure Environment Monitoring & Tuning, Azure Optimization, and end-to-end Microsoft cloud managed services. The company’s unique approach combines cost savings and value, with a focus on enhancing security and providing industry-leading customer experiences. The Henson Group serves various industries including financial services, retail, manufacturing, healthcare, and technology. David Fuess, CEO of Henson Group, said, "This award reflects our relentless pursuit of excellence and our commitment to helping our clients achieve their digital transformation goals. We are proud of our team's hard work and the strong partnerships we have built with our clients and Ingram Micro." "We are incredibly honored to receive this prestigious award from Ingram Micro," said Alex Larsson, Chief Revenue Officer at Henson Group. "This recognition is a testament to our team's dedication to delivering cloud solutions and services that drive significant value for our clients." “We are proud to recognize Henson Group’s growing success and strategic engagement with Ingram Micro,” said Jennifer Anaya, Senior Vice President, Global Marketing, Ingram Micro. “This year’s honorees are among the best in the business and continue to lead by example, evolving their services and solutions to best support the needs of their customers now and in the future. Congratulations to all our winners and thank you for playing such an important and growing role in the success of today’s global, regional, and local B2B and B2C markets.” Henson Group is a six-time Microsoft Partner of the Year and holds multiple Microsoft-certified competencies, including the exclusive Azure Expert MSP certification. This extensive experience and expertise enable Henson Group to provide tailored solutions that precisely align with customer requirements, ensuring utmost satisfaction. Henson Group has helped over 1,000 companies across various industries, including financial services, retail/CPG, manufacturing, healthcare, and technology, media & entertainment. Discover how Henson Group's cloud solutions can transform your business. Visit HensonGroup.com to learn more about the company’s comprehensive suite of services designed to optimize your IT operations and drive innovation. About the Henson Group The Henson Group is not only the industry's Generative AI expert and Microsoft's top Azure/M365 and Managed Services Provider but also a distinguished Azure Expert MSP that has achieved all of Microsoft Azure Solution Designations. Our customer-centric approach extends beyond traditional managed services, offering comprehensive solutions for your complete cloud and machine learning journey. With expertise in Azure Infrastructure and Database Migrations, Cloud Security, and more, we leverage the full spectrum of Microsoft Solutions to drive innovation and maximize your technology infrastructure's efficiency and effectiveness. For more information, please contact: Bobby Lynch Chief Marketing Officer Henson Group Bobby@HensonGroup.com (212) 220-6711 Contact Details Henson Group Bobby Lynch +1 302-597-6768 Bobby@HensonGroup.com Company Website https://hensongroup.com/

November 18, 2024 11:49 AM Eastern Standard Time

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Cboe Is Helping Lead The Retail Trading Revolution With A New Robinhood Collaboration

Benzinga

By Johnny Rice, Benzinga Henry Schwartz, Global Head of Client Engagement, Data and Access Solutions for Cboe Global Markets Inc. (Cboe: CBOE), was interviewed by Benzinga at the HOOD Summit, presented by Robinhood (NASDAQ: HOOD). Cboe Global Markets is the world’s leading derivatives and securities exchange network – operating in 27 markets globally – and facilitates trading in options, futures, equities, FX and more for all investors. The company has long been an innovator in financial products. Mr. Schwartz discussed the revolutionary growth of the retail market and how Cboe is helping drive that growth. He also spoke of the exciting collaboration with Robinhood. Watch the full interview here: Featured photo by Jason Briscoe on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 18, 2024 08:55 AM Eastern Standard Time

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News Release

OYO enters commitment with Deutsche for a loan facility

Oravel Stays Limited

Oravel Stays Limited, which operates the global travel technology brand OYO has entered into a commitment letter with Deutsche Bank AG New York Branch (“DBNY”) and Deutsche Bank Securities Inc. As a part of the arrangement, DBNY has provided the Company with a commitment for a new term loan facility to finance OYO’s recently announced acquisition of G6 Hospitality (G6). OYO recently announced its acquisition of G6 Hospitality, the leading economy lodging franchisor and parent company of the iconic Motel 6 and Studio 6 brands, from Blackstone. Earlier in this year OYO reported its first-ever profit after tax (PAT) of ~₹17 million, according to the company's annual report. The company also reported eight consecutive quarters of positive Adjusted EBITDA. OYO's Adjusted EBITDA grew by 215% to reach ~$105 million in FY 23-24, up from ~$33 million in FY 22-23. The company had also concluded an equity funding round of $175 million was led by the company's founder Ritesh Agarwal and included participation from various Indian family offices and private investors including InCred Wealth, J&A Partners, renowned investor Ashish Kacholia the family office of Mankind Pharma promoters and ASK Financial Holdings. Original article published in Tech Observer by Mohd Ujaley. Click to read in detail https://techobserver.in/news/startups/oyo-secures-deutsche-bank-loan-commitment-to-fund-g6-hospitality-acquisition-288914/ About Tech Observer Tech Observer is a premium monthly technology news magazine published from New Delhi that brings a critical perspective and analysis from a wide spectrum of government technology, enterprise IT, startups, telecom and consumer electronics. The magazine focuses on all aspects of technology usage in government organizations, public sector and enterprises, with special emphasis on the role of influencers such as senior government officials, CIOs, CTOs, CISOs and IT heads. Contact Details Tech Observer Md Ujaley, Editor, Tech Observer +1 931-358-3248 editor@techobserver.in Company Website https://www.techobserver.in

November 18, 2024 08:45 AM Eastern Standard Time

Presenting Encouraging Data, Acquiring Licenses, Issuing Patents And More – BioRestorative's Inroads Bringing Its Stem Cell Therapies To Market

Benzinga

By Meg Flippin, Benzinga From alleviating lower back pain to treating obesity, stem cells can play a central role in healing some of the world’s most prevalent conditions. For good reason: stem cells are regenerative and can turbocharge the body's natural healing process. BioRestorative Therapies, Inc. (NASDAQ: BRTX), a regenerative medicine company focused on stem cell-based therapies and products, has been inkling deals and securing patents to treat back pain and obesity as well as other hard-to-cure ailments and diseases. Take BRTX-100 for example. It’s BioRestorative’s autologous stem cell product for chronic lower back pain. It uses a patient’s stem cells, which are harvested, cultured and then injected directly into the affected disc to start the repair process. BRTX-100 is designed to treat the 25 million people in the U.S. who suffer from chronic lower back pain each year, half of whom have or will be diagnosed with disc degeneration, reports the company, and current treatments on the market are less than ideal. Opioid pain relievers, steroid injections and physical therapy help manage pain but don’t cure it. Surgery is another option, but clinical outcomes can be limited. Phase 2 Trial Results Coming The company is currently engaged in a phase 2 clinical trial using BRTX-100 to treat persistent lower back pain caused by painful degenerative discs. This week (Nov. 10-14), BioRestorative presented new preliminary 26–52-week blinded data from the ongoing phase 2 clinical trial at the Orthopaedic Research Society (ORS) Philadelphia Spine Research Society (PSRS) 7th International Spine Research Symposium in Skytop, Pennsylvania. BioRestorative will also make the data available through a public announcement. “In February 2024, we were strongly encouraged that the Visual Analog Scale, Oswestry Disability Index, Roland Morris Disability Questionnaire, and Functional Rating Index collected at 26 and 52 weeks after injection indicated a positive trend compared to the baseline with the first four patients enrolled in the study,” said BioRestorative’s CEO Lance Alstodt. “Now, at ORS PSRS 2024, we have revealed data on 10 patients. Blinded preliminary clinical data of safety and efficacy endpoints are very encouraging, with patient reported pain and function outcomes demonstrating a positive trend,” said Mr. Alstodt. “Most importantly, at 26 weeks, 70% of the patients are reporting a significantly greater than 30% increase in function and a more than 30% decrease in pain. If data continues with this trend, we are confident that we will hit our efficacy end points for the phase 2 trial,” he continued Fighting Obesity With Stem Cells With A Focus On Growing IP Portfolio Then there is BioRestorative’s ThermoStem, which uses brown adipose-derived (brown fat) stem cells to generate new brown fat tissue to target obesity and metabolic disorders. This type of fat is known to burn rather than store energy. Elevated levels of brown fat have been shown to increase metabolism and facilitate weight loss, reports BioRestorative. It’s a big market for BioRestorative to go after. After all, 40% of Americans are obese; 30% have type 2 diabetes or pre-diabetes and half of Americans have at least one major risk factor for heart disease, according to data compiled by the company. ThermoStem is also making news with BioRestorative recently announcing that the Israel Patent Office has issued the company a Notice of Allowance for a new patent application (Israeli Patent Appl. No. 287557) covering several fundamental aspects of its allogeneic, off-the-shelf ThermoStem platform. It's the 14th international patent and covers non-naturally occurring three-dimensional brown adipose-derived stem cell (BADSC) aggregates, encapsulation, a method for making them and a method for treating a patient with a disorder. “We believe that our ThermoStem-based BADSCs hold tremendous promise to deliver a superior efficacy and tolerability profile over GLP-1 drugs,” said Alstodt. “This latest patent issuance demonstrates our strong commitment to protecting the innovation of our ThermoStem program and the significant potential commercial opportunity that it represents for ourselves and any current and/or future potential licensing partners. And, given Israel’s global prominence in stem cell research, we are particularly excited by this latest patent issuance.” Expanding Via Licensing In addition to securing patents and gearing up to present clinical data, BioRestorative recently obtained a license from the New York State Department of Health (NYSDOH) to process, isolate, expand and preserve allogeneic (non-autologous) donor tissue, including stem cells, for medical research. In New York, companies are required to have a license to engage in tissue and stem cell activities. Previously BioRestorative was licensed by the NYSDOH to act as a tissue bank for the processing of mesenchymal stem cells derived from autologous donors only. BioRestorative says the expanded license enables it to leverage its state-of-the-art cGMP manufacturing to process, bank and distribute clinical-grade allogeneic (off-the-shelf) biologics. “It will significantly enhance our ability to develop an unrivaled clinical pipeline of off-the-shelf cell-based biologic products,” says Alstodt. Stem cells play an important role in treating several prevalent diseases. The remedies of today aren’t cutting it. BioRestorative aims to change that with BRTX-100 and ThermoStem – and it’s working hard to get the licenses and patents to make that happen. Other companies competing in the cell-based biologics or chronic pain treatment space include Mesoblast ( NASDAQ: MESO), Brainstorm Cell Therapeutic (NASDAQ: BCLI) and Longeveron (NASDAQ: LGVN). To learn more about BioRestorative’s stem cell therapies, click here. Featured photo by Sasun Bughdaryan on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 18, 2024 08:45 AM Eastern Standard Time

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The Crossroads Summit 2024 Is Just Days Away – Get Your Tickets Now To Gain Insights About A Changing World From Renowned Minds

Benzinga

By Josh Enomoto, Benzinga While all eyes may be on the election of former President Donald Trump to a second non-consecutive term, that’s just one of the critical catalysts that stand poised to potentially forever change the investment landscape. That’s why there’s not a moment to miss, and concerned market participants may want to attend the upcoming Crossroads Summit 2024 to prepare for the future. Held in beautiful Miami, FL, Crossroads will bring together some of the brightest minds across finance, applied science and geopolitics. Between Nov. 21 and Nov. 22, renowned experts will share their blueprint for a global ecosystem undergoing radical transitions. Thanks to the rapid social integration of advanced technologies such as artificial intelligence and machine learning, the economy will likely separate investors into two categories: the prepared and everyone else. With only days left for the conference, prospective attendees should make their decision quickly. Following a breakfast and welcoming session by host Karl Sprague and keynote speaker John Bartleman of TradeStation – the title sponsor of the summit — the expert panel will jump right into the thick of things. Given the dynamic environment that’s likely to evolve rapidly, interested investors have little time to waste. Positioning America In A Shifting World Order Right off the bat, Crossroads Summit 2024 kicks off on day one with Peter Zeihan, one of the foremost figures in the field of geopolitical analysis. In his keynote address, “Navigating the End of the World: Geopolitics and the Future of America,” Zeihan offers timely and critical insight into how significant evolutions in global power structures are changing the landscape for U.S. investors. Most notably, Russia’s ongoing invasion of Ukraine represents one of the most dangerous flashpoints in world affairs. In addition, Americans must take note of brewing tensions in China and how these and other factors could impact markets both domestically and abroad. With his inimitable wit and dry humor, Zeihan will provide investors with nuanced context to help investors properly map their decisions. Bracing For Potentially Radical Change In Domestic Policy On the eve of the 2024 presidential election, Vice President Kamala Harris appeared to command the polling advantage. However, when the actual ballots were submitted, President-elect Trump successfully completed a surprising comeback. Subsequently, the opposing Democrats launched into a blame game, but a loss may have been inevitable. Globally, other incumbent political parties suffered defeats amid a populist backlash, as well. This backdrop presents rich grounds for the next panel of industry experts, including Michael Khouw from CNBC, Mike McGlone from Bloomberg, and Katheryn Rooney Vera from StoneX. Saif Ishoof will moderate the discussion, titled “Strategic Adaptation: Preparing for Turbulence in the U.S. Landscape,” which will shine a light on the uncertainties of domestic policy shifts under a second Trump term and how investors may navigate them. Preparing For A Possible Inflection Point With the stratospheric rise of both equities and cryptocurrencies in the post-pandemic cycle, it’s easy to get lulled into a sense of complacency. However, author Neil Howe – an expert on generational cycles – will argue in his discussion “The Fourth Turning: Navigating Crisis and Renewal” that investors need to be more vigilant about contemporary events. Essentially, the good times might not continue unabated. According to Howe’s theory, major historical events are tied to recurring cycles, with each ebb and flow potentially lasting decades. Therefore, while the present bullish framework in global capital markets may entice an acquisitive posture, it’s vital to consider past crises and periods of renewal to properly understand the current juncture. Potential blind spots may include the rise of China and the Biden administration’s subsequent crackdown on the nation’s tech industry. Following a lunch break, moderator Bryan Gorrita will guide a panel of distinguished figures: Mike Green from Simplify Asset Management, Susan Lindeque, founder and CEO of Avestix Group and Luke Gromen of Forest for the Trees. Together, the experts will discuss methods of profiting from the potential turbulence and volatility catapulted by the upcoming “Fourth Turning.” Battening Down The Hatches In one of the most anticipated keynote addresses, economist and author Alan Beaulieu will discuss the potential for a radical paradigm shift that may erupt in the 2030s decade. As co-author of Prosperity in the Age of Decline, Beaulieu adopts a futurist mentality, offering practical and insightful guidance on boosting profits irrespective of business cycle changes. However, because of the nature of contemporary global markets, the expert anticipates a sobering scenario over the next few years. His discussion, “Forecasting the Future: Economic Collapse in the 2030s,” offers a much-needed blueprint on the conditions that could lead to ruin – and most importantly, what investors can do right now to protect their wealth. If there were just one reason to attend the Crossroads Summit 2024, this talking point may very well be it. The Age Of The Machines Finally, conference attendees will gain greater appreciation and knowledge of perhaps the most transformative digital innovation since the rise of the internet: AI and its capacity to positively disrupt multiple sectors, including finance, healthcare and manufacturing. Driving this discussion will be Michael Jabbour, Chief Innovation Officer at Microsoft (NASDAQ: MSFT). Among the foremost leaders in integrating the broader digital transformation, Jabbour specializes in the acceleration and personalization of learning. In addition, his role at Microsoft enables him to empower both educators and students with knowledge about the transformative and ethical application of AI. Through his address, investors can learn firsthand how AI can improve efficiency and, therefore, the bottom line. With multiple enterprises aligned with the generative AI ecosystem racing toward a $4 trillion valuation, this is a discussion investors can’t afford to miss. The Must-Watch Event Of The Year Is Coming Soon With global instability, economic uncertainty and technological disruption defining the landscape of the new economy, Crossroads Summit 2024 kicks off with a key opportunity for investors to learn strategies to navigate uncertainty. From understanding the future of geopolitics to preparing for the next potential economic collapse, the insights shared at this event are more relevant than ever. Investors who attend will be equipped with the knowledge and strategies needed to navigate the complexities of the evolving paradigm. Don’t miss out on this chance to hear from industry leaders and innovators who are shaping the future. Right from the first day, Crossroads is set to offer the guidance and foresight that investors need to thrive in the years to come. Grab your tickets for the 2024 Crossroads Summit and learn how some of America’s most renowned thought leaders are making order out of chaos by clicking here! Featured photo by PIRO by Pixabay. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 18, 2024 08:35 AM Eastern Standard Time

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